Benefits of Coriandrum sativum L. seed extract in Maintaining Immunocompetent Cell Homeostasis

Diabetes mellitus (DM) is a metabolic disease followed by an increase in blood glucose and impaired metabolism of proteins, lipids carbohydrates. In general, these conditions are caused insulin secretion and/or defects receptors. As yet, there no effective drug capable treating DM. Manifestations DM worsen when accompanied severe inflammation. Therefore, the avoiding strategy management inflammation primary courses action preventing further damage. this study, we had evidence that Coriandrum sativum L. extract (CSE) could be used as alternative to relieve symptoms mice model. Previously, CSE has been shown able inhibit synthesis pro-inflammatory molecule interleukin (IL)-6 both B220 CD11b cells. Here, showed prevents over-activation CD4 CD8 T lymphocytes. The predominance cells expressing CD62L on after administration indicated were obstacles activation. also suppressed excessive CD25 expression, causing expression return normal levels. Thus, study therapeutic activity model suppressing cytokines, modulate activation naïve cells, maintain population CD4+CD25+